Platelet basic protein (PPBP)

About Platelet basic protein

Platelet basic protein (PPBP) is a protein from Homo sapiens identified by UniProt accession P02775, 128 residues long. MolForge cross-references it against 0 known binders and 452 disease associations.

Target properties

Protein name	Platelet basic protein
UniProt accession	P02775
Gene	PPBP
Organism	Homo sapiens
Length	128 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (452)

Diseases linked to this target (Open Targets).

glioblastoma multiforme · score 0.27
ovarian cancer · score 0.26
breast adenocarcinoma · score 0.26
head and neck squamous cell carcinoma · score 0.16
neuroblastoma · score 0.11
neoplasm · score 0.09
non-small cell lung carcinoma · score 0.09
Rheumatoid arthritis · score 0.08
atrial fibrillation · score 0.08
renal cell carcinoma · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P02775-F1	alphafold	PREDICTED	77.46	—

Amino-acid sequence (128 residues)

MSLRLDTTPS CNSARPLHAL QVLLLLSLLL TALASSTKGQ TKRNLAKGKE ESLDSDLYAE LRCMCIKTTS GIHPKNIQSL EVIGKGTHCN QVEVIATLKD GRKICLDPDA PRIKKIVQKK LAGDESAD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards