About Ferritin heavy chain
Ferritin heavy chain (FTH1) is a protein
from Homo sapiens identified by UniProt accession
P02794, 183 residues long.
MolForge cross-references it against 0 known binders and
333 disease associations.
Target properties
| Protein name | Ferritin heavy chain |
|---|
| UniProt accession | P02794 |
|---|
| Gene | FTH1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 183 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (333)
Diseases linked to this target (Open Targets).
- autosomal recessive bestrophinopathy · score 0.51
- vitelliform macular dystrophy 2 · score 0.51
- hemochromatosis type 5 · score 0.50
- Retinal dystrophy · score 0.48
- FTH1-related iron overload · score 0.47
- Stargardt disease · score 0.40
- CHARGE syndrome · score 0.34
- autosomal dominant vitreoretinochoroidopathy · score 0.33
- Red cell distribution width · score 0.25
- squamous cell lung carcinoma · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P02794-F1 | alphafold | PREDICTED | 95.33 | — |
Amino-acid sequence (183 residues)
MTTASTSQVR QNYHQDSEAA INRQINLELY ASYVYLSMSY YFDRDDVALK NFAKYFLHQS HEEREHAEKL MKLQNQRGGR IFLQDIKKPD CDDWESGLNA MECALHLEKN VNQSLLELHK LATDKNDPHL CDFIETHYLN EQVKAIKELG DHVTNLRKMG APESGLAEYL FDKHTLGDSD NES
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