Basic salivary proline-rich protein 2 (PRB2)

About Basic salivary proline-rich protein 2

Basic salivary proline-rich protein 2 (PRB2) is a protein from Homo sapiens identified by UniProt accession P02812, 416 residues long. MolForge cross-references it against 0 known binders and 159 disease associations.

Target properties

Protein name	Basic salivary proline-rich protein 2
UniProt accession	P02812
Gene	PRB2
Organism	Homo sapiens
Length	416 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (159)

Diseases linked to this target (Open Targets).

subcutaneous adipose tissue measurement · score 0.04
central nervous system cancer · score 0.03
human african trypanosomiasis · score 0.03
psoriasis · score 0.03
malaria · score 0.02
alkaline phosphatase measurement · score 0.02
Systemic lupus erythematosus · score 0.02
systemic scleroderma · score 0.02
parkinsonism-dystonia, infantile · score 0.01
Infantile dystonia-parkinsonism · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P02812-F1	alphafold	PREDICTED	46.66	—

Amino-acid sequence (416 residues)

MLLILLSVAL LALSSAQNLN EDVSQEESPS LIAGNPQGAP PQGGNKPQGP PSPPGKPQGP PPQGGNQPQG PPPPPGKPQG PPPQGGNKPQ GPPPPGKPQG PPPQGDKSRS PRSPPGKPQG PPPQGGNQPQ GPPPPPGKPQ GPPPQGGNKP QGPPPPGKPQ GPPPQGDNKS RSSRSPPGKP QGPPPQGGNQ PQGPPPPPGK PQGPPPQGGN KPQGPPPPGK PQGPPPQGDN KSQSARSPPG KPQGPPPQGG NQPQGPPPPP GKPQGPPPQG GNKPQGPPPP GKPQGPPPQG GSKSRSSRSP PGKPQGPPPQ GGNQPQGPPP PPGKPQGPPP QGGNKPQGPP PPGKPQGPPP QGGSKSRSAR SPPGKPQGPP QQEGNNPQGP PPPAGGNPQQ PQAPPAGQPQ GPPRPPQGGR PSRPPQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards