Osteocalcin (BGLAP)

About Osteocalcin

Osteocalcin (BGLAP) is a protein from Homo sapiens identified by UniProt accession P02818, 100 residues long. MolForge cross-references it against 0 known binders and 745 disease associations.

Target properties

Protein name	Osteocalcin
UniProt accession	P02818
Gene	BGLAP
Organism	Homo sapiens
Length	100 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (745)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.37
type 2 diabetes mellitus · score 0.10
metabolic syndrome · score 0.09
coronary artery disease · score 0.08
hepatocellular carcinoma · score 0.08
periodontitis · score 0.08
mosaic loss of chromosome Y measurement · score 0.07
gestational diabetes · score 0.07
cardiovascular disease · score 0.06
serum urea measurement · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P02818-F1	alphafold	PREDICTED	76.00	—

Amino-acid sequence (100 residues)

MRALTLLALL ALAALCIAGQ AGAKPSGAES SKGAAFVSKQ EGSEVVKRPR RYLYQWLGAP VPYPDPLEPR REVCELNPDC DELADHIGFQ EAYRRFYGPV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards