About NADH-ubiquinone oxidoreductase chain 2
NADH-ubiquinone oxidoreductase chain 2 (MT-ND2) is a protein
from Homo sapiens identified by UniProt accession
P03891, 347 residues long.
MolForge cross-references it against 0 known binders and
341 disease associations.
Target properties
| Protein name | NADH-ubiquinone oxidoreductase chain 2 |
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| UniProt accession | P03891 |
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| Gene | MT-ND2 |
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| Organism | Homo sapiens |
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| Length | 347 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (341)
Diseases linked to this target (Open Targets).
- Leber hereditary optic neuropathy · score 0.73
- Leigh syndrome · score 0.69
- mitochondrial disease · score 0.67
- mitochondrial complex I deficiency · score 0.67
- type 2 diabetes mellitus · score 0.61
- diabetes mellitus · score 0.60
- polycystic ovary syndrome · score 0.60
- mitochondrial non-syndromic sensorineural hearing loss · score 0.59
- Mitochondrial non-syndromic sensorineural deafness · score 0.59
- type 1 diabetes mellitus · score 0.59
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P03891-F1 | alphafold | PREDICTED | 95.15 | — |
Amino-acid sequence (347 residues)
MNPLAQPVIY STIFAGTLIT ALSSHWFFTW VGLEMNMLAF IPVLTKKMNP RSTEAAIKYF LTQATASMIL LMAILFNNML SGQWTMTNTT NQYSSLMIMM AMAMKLGMAP FHFWVPEVTQ GTPLTSGLLL LTWQKLAPIS IMYQISPSLN VSLLLTLSIL SIMAGSWGGL NQTQLRKILA YSSITHMGWM MAVLPYNPNM TILNLTIYII LTTTAFLLLN LNSSTTTLLL SRTWNKLTWL TPLIPSTLLS LGGLPPLTGF LPKWAIIEEF TKNNSLIIPT IMATITLLNL YFYLRLIYST SITLLPMSNN VKMKWQFEHT KPTPFLPTLI ALTTLLLPIS PFMLMIL
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