NADH-ubiquinone oxidoreductase chain 3 (MT-ND3)

About NADH-ubiquinone oxidoreductase chain 3

NADH-ubiquinone oxidoreductase chain 3 (MT-ND3) is a protein from Homo sapiens identified by UniProt accession P03897, 115 residues long. MolForge cross-references it against 0 known binders and 295 disease associations.

Target properties

Protein name	NADH-ubiquinone oxidoreductase chain 3
UniProt accession	P03897
Gene	MT-ND3
Organism	Homo sapiens
Length	115 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (295)

Diseases linked to this target (Open Targets).

Leigh syndrome · score 0.75
mitochondrial complex I deficiency · score 0.69
mitochondrial disease · score 0.67
type 2 diabetes mellitus · score 0.61
diabetes mellitus · score 0.60
polycystic ovary syndrome · score 0.60
type 1 diabetes mellitus · score 0.58
gestational diabetes · score 0.58
obesity · score 0.57
MELAS · score 0.56

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P03897-F1	alphafold	PREDICTED	91.86	—

Amino-acid sequence (115 residues)

MNFALILMIN TLLALLLMII TFWLPQLNGY MEKSTPYECG FDPMSPARVP FSMKFFLVAI TFLLFDLEIA LLLPLPWALQ TTNLPLMVMS SLLLIIILAL SLAYEWLQKG LDWTE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards