NADH-ubiquinone oxidoreductase chain 4L (MT-ND4L)

About NADH-ubiquinone oxidoreductase chain 4L

NADH-ubiquinone oxidoreductase chain 4L (MT-ND4L) is a protein from Homo sapiens identified by UniProt accession P03901, 98 residues long. MolForge cross-references it against 0 known binders and 264 disease associations.

Target properties

Protein name	NADH-ubiquinone oxidoreductase chain 4L
UniProt accession	P03901
Gene	MT-ND4L
Organism	Homo sapiens
Length	98 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (264)

Diseases linked to this target (Open Targets).

Leber hereditary optic neuropathy · score 0.68
type 2 diabetes mellitus · score 0.61
diabetes mellitus · score 0.60
polycystic ovary syndrome · score 0.60
type 1 diabetes mellitus · score 0.58
gestational diabetes · score 0.58
mitochondrial disease · score 0.57
obesity · score 0.57
MELAS syndrome · score 0.56
MELAS · score 0.56

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P03901-F1	alphafold	PREDICTED	88.65	—

Amino-acid sequence (98 residues)

MPLIYMNIML AFTISLLGML VYRSHLMSSL LCLEGMMLSL FIMATLMTLN THSLLANIVP IAMLVFAACE AAVGLALLVS ISNTYGLDYV HNLNLLQC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards