NADH-ubiquinone oxidoreductase chain 6 (MT-ND6)

About NADH-ubiquinone oxidoreductase chain 6

NADH-ubiquinone oxidoreductase chain 6 (MT-ND6) is a protein from Homo sapiens identified by UniProt accession P03923, 174 residues long. MolForge cross-references it against 0 known binders and 348 disease associations.

Target properties

Protein name	NADH-ubiquinone oxidoreductase chain 6
UniProt accession	P03923
Gene	MT-ND6
Organism	Homo sapiens
Length	174 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (348)

Diseases linked to this target (Open Targets).

Leber hereditary optic neuropathy · score 0.79
Leigh syndrome · score 0.72
MELAS syndrome · score 0.70
Leber plus disease · score 0.67
mitochondrial disease · score 0.66
MELAS · score 0.66
type 2 diabetes mellitus · score 0.62
diabetes mellitus · score 0.60
polycystic ovary syndrome · score 0.60
type 1 diabetes mellitus · score 0.58

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P03923-F1	alphafold	PREDICTED	84.80	—

Amino-acid sequence (174 residues)

MMYALFLLSV GLVMGFVGFS SKPSPIYGGL VLIVSGVVGC VIILNFGGGY MGLMVFLIYL GGMMVVFGYT TAMAIEEYPE AWGSGVEVLV SVLVGLAMEV GLVLWVKEYD GVVVVVNFNS VGSWMIYEGE GSGLIREDPI GAGALYDYGR WLVVVTGWTL FVGVYIVIEI ARGN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards