ATP synthase F(0) complex subunit 8 (MT-ATP8)

About ATP synthase F(0) complex subunit 8

ATP synthase F(0) complex subunit 8 (MT-ATP8) is a protein from Homo sapiens identified by UniProt accession P03928, 68 residues long. MolForge cross-references it against 0 known binders and 115 disease associations.

Target properties

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Disease associations (115)

Diseases linked to this target (Open Targets).

• Mitochondrial disease with hypertrophic cardiomyopathy · score 0.66
• Rare familial disorder with hypertrophic cardiomyopathy · score 0.61
• mitochondrial disease · score 0.57
• MELAS syndrome · score 0.57
• MELAS · score 0.57
• leigh syndrome due to mitochondrial complex iv deficiency · score 0.52
• mitochondrial complex IV deficiency, nuclear type 22 · score 0.52
• MERRF · score 0.52
• MERRF syndrome · score 0.52
• mitochondrial non-syndromic sensorineural hearing loss · score 0.49

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Amino-acid sequence (68 residues)

External references