Short-wave-sensitive opsin 1 (OPN1SW)

About Short-wave-sensitive opsin 1

Short-wave-sensitive opsin 1 (OPN1SW) is a protein from Homo sapiens identified by UniProt accession P03999, 345 residues long. MolForge cross-references it against 0 known binders and 181 disease associations.

Target properties

Protein name	Short-wave-sensitive opsin 1
UniProt accession	P03999
Gene	OPN1SW
Organism	Homo sapiens
Length	345 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (181)

Diseases linked to this target (Open Targets).

Tritanopia · score 0.73
blue color blindness · score 0.70
neurodegenerative disease · score 0.31
atrial fibrillation · score 0.23
breast adenocarcinoma · score 0.22
cutaneous melanoma · score 0.17
mathematical ability · score 0.15
alcohol consumption measurement · score 0.13
atrial flutter · score 0.12
self reported educational attainment · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P03999-F1	alphafold	PREDICTED	86.94	—

Amino-acid sequence (345 residues)

MSEEEFYLFK NISSVGPWDG PQYHIAPVWA FYLQAAFMGT VFLIGFPLNA MVLVATLRYK KLRQPLNYIL VNVSFGGFLL CIFSVFPVFV ASCNGYFVFG RHVCALEGFL GTVAGLVTGW SLAFLAFERY IVICKPFGNF RFSSKHALTV VLATWTIGIG VSIPPFFGWS RFIPEGLQCS CGPDWYTVGT KYRSESYTWF LFIFCFIVPL SLICFSYTQL LRALKAVAAQ QQESATTQKA EREVSRMVVV MVGSFCVCYV PYAAFAMYMV NNRNHGLDLR LVTIPSFFSK SACIYNPIIY CFMNKQFQAC IMKMVCGKAM TDESDTCSSQ KTEVSTVSST QVGPN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards