Long-wave-sensitive opsin 1 (OPN1LW)

About Long-wave-sensitive opsin 1

Long-wave-sensitive opsin 1 (OPN1LW) is a protein from Homo sapiens identified by UniProt accession P04000, 364 residues long. MolForge cross-references it against 0 known binders and 93 disease associations.

Target properties

Protein name	Long-wave-sensitive opsin 1
UniProt accession	P04000
Gene	OPN1LW
Organism	Homo sapiens
Length	364 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (93)

Diseases linked to this target (Open Targets).

Blue cone monochromatism · score 0.65
blue cone monochromacy · score 0.60
red color blindness · score 0.59
red-green color blindness · score 0.56
Progressive cone dystrophy · score 0.46
Cone rod dystrophy · score 0.38
vaginal discharge · score 0.30
breast adenocarcinoma · score 0.22
cutaneous melanoma · score 0.17
low grade glioma · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P04000-F1	alphafold	PREDICTED	82.16	—

Amino-acid sequence (364 residues)

MAQQWSLQRL AGRHPQDSYE DSTQSSIFTY TNSNSTRGPF EGPNYHIAPR WVYHLTSVWM IFVVTASVFT NGLVLAATMK FKKLRHPLNW ILVNLAVADL AETVIASTIS IVNQVSGYFV LGHPMCVLEG YTVSLCGITG LWSLAIISWE RWMVVCKPFG NVRFDAKLAI VGIAFSWIWA AVWTAPPIFG WSRYWPHGLK TSCGPDVFSG SSYPGVQSYM IVLMVTCCII PLAIIMLCYL QVWLAIRAVA KQQKESESTQ KAEKEVTRMV VVMIFAYCVC WGPYTFFACF AAANPGYAFH PLMAALPAYF AKSATIYNPV IYVFMNRQFR NCILQLFGKK VDDGSELSSA SKTEVSSVSS VSPA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards