Medium-wave-sensitive opsin 1 (OPN1MW)

About Medium-wave-sensitive opsin 1

Medium-wave-sensitive opsin 1 (OPN1MW) is a protein from Homo sapiens identified by UniProt accession P04001, 364 residues long. MolForge cross-references it against 0 known binders and 133 disease associations.

Target properties

Protein name	Medium-wave-sensitive opsin 1
UniProt accession	P04001
Gene	OPN1MW
Organism	Homo sapiens
Length	364 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (133)

Diseases linked to this target (Open Targets).

red-green color blindness · score 0.69
Blue cone monochromatism · score 0.63
blue cone monochromacy · score 0.62
Progressive cone dystrophy · score 0.55
Cone rod dystrophy · score 0.50
achromatopsia · score 0.34
red color blindness · score 0.10
Tritanopia · score 0.08
Myopia · score 0.07
bradyopsia · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P04001-F1	alphafold	PREDICTED	82.92	—

Amino-acid sequence (364 residues)

MAQQWSLQRL AGRHPQDSYE DSTQSSIFTY TNSNSTRGPF EGPNYHIAPR WVYHLTSVWM IFVVIASVFT NGLVLAATMK FKKLRHPLNW ILVNLAVADL AETVIASTIS VVNQVYGYFV LGHPMCVLEG YTVSLCGITG LWSLAIISWE RWMVVCKPFG NVRFDAKLAI VGIAFSWIWA AVWTAPPIFG WSRYWPHGLK TSCGPDVFSG SSYPGVQSYM IVLMVTCCIT PLSIIVLCYL QVWLAIRAVA KQQKESESTQ KAEKEVTRMV VVMVLAFCFC WGPYAFFACF AAANPGYPFH PLMAALPAFF AKSATIYNPV IYVFMNRQFR NCILQLFGKK VDDGSELSSA SKTEVSSVSS VSPA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards