About C4b-binding protein alpha chain
C4b-binding protein alpha chain (C4BPA) is a protein
from Homo sapiens identified by UniProt accession
P04003, 597 residues long.
MolForge cross-references it against 0 known binders and
158 disease associations.
Target properties
| Protein name | C4b-binding protein alpha chain |
|---|
| UniProt accession | P04003 |
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| Gene | C4BPA |
|---|
| Organism | Homo sapiens |
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| Length | 597 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (158)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.44
- venous thromboembolism · score 0.35
- platelet component distribution width · score 0.35
- mean platelet volume · score 0.33
- reticulocyte count · score 0.25
- neurodegenerative disease · score 0.24
- lysosomal storage disease · score 0.24
- Alzheimer disease · score 0.24
- Parkinson disease · score 0.24
- multiple sclerosis · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P04003-F1 | alphafold | PREDICTED | 81.74 | — |
Amino-acid sequence (597 residues)
MHPPKTPSGA LHRKRKMAAW PFSRLWKVSD PILFQMTLIA ALLPAVLGNC GPPPTLSFAA PMDITLTETR FKTGTTLKYT CLPGYVRSHS TQTLTCNSDG EWVYNTFCIY KRCRHPGELR NGQVEIKTDL SFGSQIEFSC SEGFFLIGST TSRCEVQDRG VGWSHPLPQC EIVKCKPPPD IRNGRHSGEE NFYAYGFSVT YSCDPRFSLL GHASISCTVE NETIGVWRPS PPTCEKITCR KPDVSHGEMV SGFGPIYNYK DTIVFKCQKG FVLRGSSVIH CDADSKWNPS PPACEPNSCI NLPDIPHASW ETYPRPTKED VYVVGTVLRY RCHPGYKPTT DEPTTVICQK NLRWTPYQGC EALCCPEPKL NNGEITQHRK SRPANHCVYF YGDEISFSCH ETSRFSAICQ GDGTWSPRTP SCGDICNFPP KIAHGHYKQS SSYSFFKEEI IYECDKGYIL VGQAKLSCSY SHWSAPAPQC KALCRKPELV NGRLSVDKDQ YVEPENVTIQ CDSGYGVVGP QSITCSGNRT WYPEVPKCEW ETPEGCEQVL TGKRLMQCLP NPEDVKMALE VYKLSLEIEQ LELQRDSARQ STLDKEL
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