Catalase (CAT)

About Catalase

Catalase (CAT) is a protein from Homo sapiens identified by UniProt accession P04040, 527 residues long. MolForge cross-references it against 0 known binders and 1,074 disease associations.

Target properties

Protein name	Catalase
UniProt accession	P04040
Gene	CAT
Organism	Homo sapiens
Length	527 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (1074)

Diseases linked to this target (Open Targets).

acatalasia · score 0.72
blood protein measurement · score 0.32
catalase measurement · score 0.29
neurodegenerative disease · score 0.22
cutaneous melanoma · score 0.18
breast adenocarcinoma · score 0.18
neoplasm · score 0.12
hepatocellular carcinoma · score 0.10
type 2 diabetes mellitus · score 0.10
pancreatic adenocarcinoma · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P04040-F1	alphafold	PREDICTED	95.79	—

Amino-acid sequence (527 residues)

MADSRDPASD QMQHWKEQRA AQKADVLTTG AGNPVGDKLN VITVGPRGPL LVQDVVFTDE MAHFDRERIP ERVVHAKGAG AFGYFEVTHD ITKYSKAKVF EHIGKKTPIA VRFSTVAGES GSADTVRDPR GFAVKFYTED GNWDLVGNNT PIFFIRDPIL FPSFIHSQKR NPQTHLKDPD MVWDFWSLRP ESLHQVSFLF SDRGIPDGHR HMNGYGSHTF KLVNANGEAV YCKFHYKTDQ GIKNLSVEDA ARLSQEDPDY GIRDLFNAIA TGKYPSWTFY IQVMTFNQAE TFPFNPFDLT KVWPHKDYPL IPVGKLVLNR NPVNYFAEVE QIAFDPSNMP PGIEASPDKM LQGRLFAYPD THRHRLGPNY LHIPVNCPYR ARVANYQRDG PMCMQDNQGG APNYYPNSFG APEQQPSALE HSIQYSGEVR RFNTANDDNV TQVRAFYVNV LNEEQRKRLC ENIAGHLKDA QIFIQKKAVK NFTEVHPDYG SHIQALLDKY NAEKPKNAIH TFVQSGSHLA AREKANL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards