Tissue alpha-L-fucosidase (FUCA1)

About Tissue alpha-L-fucosidase

Tissue alpha-L-fucosidase (FUCA1) is a protein from Homo sapiens identified by UniProt accession P04066, 466 residues long. MolForge cross-references it against 0 known binders and 192 disease associations.

Target properties

Protein name	Tissue alpha-L-fucosidase
UniProt accession	P04066
Gene	FUCA1
Organism	Homo sapiens
Length	466 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (192)

Diseases linked to this target (Open Targets).

fucosidosis · score 0.84
genetic disorder · score 0.41
Intellectual disability · score 0.37
Seizure · score 0.37
Abnormality of the nervous system · score 0.34
lymphocyte count · score 0.26
reticulocyte count · score 0.26
reticulocyte measurement · score 0.23
eosinophil count · score 0.21
Immature Reticulocyte Fraction Measurement · score 0.21

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P04066-F1	alphafold	PREDICTED	93.19	—

Amino-acid sequence (466 residues)

MRAPGMRSRP AGPALLLLLL FLGAAESVRR AQPPRRYTPD WPSLDSRPLP AWFDEAKFGV FIHWGVFSVP AWGSEWFWWH WQGEGRPQYQ RFMRDNYPPG FSYADFGPQF TARFFHPEEW ADLFQAAGAK YVVLTTKHHE GFTNWPSPVS WNWNSKDVGP HRDLVGELGT ALRKRNIRYG LYHSLLEWFH PLYLLDKKNG FKTQHFVSAK TMPELYDLVN SYKPDLIWSD GEWECPDTYW NSTNFLSWLY NDSPVKDEVV VNDRWGQNCS CHHGGYYNCE DKFKPQSLPD HKWEMCTSID KFSWGYRRDM ALSDVTEESE IISELVQTVS LGGNYLLNIG PTKDGLIVPI FQERLLAVGK WLSINGEAIY ASKPWRVQWE KNTTSVWYTS KGSAVYAIFL HWPENGVLNL ESPITTSTTK ITMLGIQGDL KWSTDPDKGL FISLPQLPPS AVPAEFAWTI KLTGVK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards