Vitamin K-dependent protein C (PROC)

About Vitamin K-dependent protein C

Vitamin K-dependent protein C (PROC) is a protein from Homo sapiens identified by UniProt accession P04070, 461 residues long. MolForge cross-references it against 0 known binders and 277 disease associations.

Target properties

Protein name	Vitamin K-dependent protein C
UniProt accession	P04070
Gene	PROC
Organism	Homo sapiens
Length	461 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (277)

Diseases linked to this target (Open Targets).

protein c deficiency · score 0.81
hereditary thrombophilia due to congenital protein C deficiency · score 0.78
Abnormal thrombosis · score 0.63
deep vein thrombosis · score 0.59
Thrombophlebitis · score 0.58
Phlebitis · score 0.56
venous thromboembolism · score 0.54
Portal vein thrombosis · score 0.54
hematologic disease · score 0.41
Venous thrombosis · score 0.40

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P04070-F1	alphafold	PREDICTED	82.75	—

Amino-acid sequence (461 residues)

MWQLTSLLLF VATWGISGTP APLDSVFSSS ERAHQVLRIR KRANSFLEEL RHSSLERECI EEICDFEEAK EIFQNVDDTL AFWSKHVDGD QCLVLPLEHP CASLCCGHGT CIDGIGSFSC DCRSGWEGRF CQREVSFLNC SLDNGGCTHY CLEEVGWRRC SCAPGYKLGD DLLQCHPAVK FPCGRPWKRM EKKRSHLKRD TEDQEDQVDP RLIDGKMTRR GDSPWQVVLL DSKKKLACGA VLIHPSWVLT AAHCMDESKK LLVRLGEYDL RRWEKWELDL DIKEVFVHPN YSKSTTDNDI ALLHLAQPAT LSQTIVPICL PDSGLAEREL NQAGQETLVT GWGYHSSREK EAKRNRTFVL NFIKIPVVPH NECSEVMSNM VSENMLCAGI LGDRQDACEG DSGGPMVASF HGTWFLVGLV SWGEGCGLLH NYGVYTKVSR YLDWIHGHIR DKEAPQKSWA P

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards