Fructose-bisphosphate aldolase A (ALDOA)

About Fructose-bisphosphate aldolase A

Fructose-bisphosphate aldolase A (ALDOA) is a protein from Homo sapiens identified by UniProt accession P04075, 364 residues long. MolForge cross-references it against 0 known binders and 23 disease associations.

Target properties

Protein name	Fructose-bisphosphate aldolase A
UniProt accession	P04075
Gene	ALDOA
Organism	Homo sapiens
Length	364 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (23)

Diseases linked to this target (Open Targets).

glycogen storage disease due to aldolase A deficiency · score 0.82
disorder of glycogen metabolism · score 0.54
neurodegenerative disease · score 0.31
breast adenocarcinoma · score 0.25
appendicular lean mass · score 0.21
risk-taking behaviour · score 0.20
genetic disorder · score 0.18
monocyte count · score 0.15
cataract · score 0.12
endometrial cancer · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P04075-F1	alphafold	PREDICTED	96.43	—

Amino-acid sequence (364 residues)

MPYQYPALTP EQKKELSDIA HRIVAPGKGI LAADESTGSI AKRLQSIGTE NTEENRRFYR QLLLTADDRV NPCIGGVILF HETLYQKADD GRPFPQVIKS KGGVVGIKVD KGVVPLAGTN GETTTQGLDG LSERCAQYKK DGADFAKWRC VLKIGEHTPS ALAIMENANV LARYASICQQ NGIVPIVEPE ILPDGDHDLK RCQYVTEKVL AAVYKALSDH HIYLEGTLLK PNMVTPGHAC TQKFSHEEIA MATVTALRRT VPPAVTGITF LSGGQSEEEA SINLNAINKC PLLKPWALTF SYGRALQASA LKAWGGKKEN LKAAQEEYVK RALANSLACQ GKYTPSGQAG AAASESLFVS NHAY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards