Granulocyte-macrophage colony-stimulating factor…

About Granulocyte-macrophage colony-stimulating factor

Granulocyte-macrophage colony-stimulating factor (CSF2) is a protein from Homo sapiens identified by UniProt accession P04141, 144 residues long. MolForge cross-references it against 0 known binders and 1,248 disease associations.

Target properties

Protein name	Granulocyte-macrophage colony-stimulating factor
UniProt accession	P04141
Gene	CSF2
Organism	Homo sapiens
Length	144 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (1248)

Diseases linked to this target (Open Targets).

eosinophil count · score 0.44
eosinophil percentage of leukocytes · score 0.41
eosinophil percentage of granulocytes · score 0.39
rheumatoid arthritis · score 0.38
neutrophil percentage of granulocytes · score 0.37
glioblastoma multiforme · score 0.32
COVID-19 · score 0.32
hepatocellular carcinoma · score 0.31
neurodegenerative disease · score 0.29
pneumonia · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P04141-F1	alphafold	PREDICTED	87.72	—

Amino-acid sequence (144 residues)

MWLQSLLLLG TVACSISAPA RSPSPSTQPW EHVNAIQEAR RLLNLSRDTA AEMNETVEVI SEMFDLQEPT CLQTRLELYK QGLRGSLTKL KGPLTMMASH YKQHCPPTPE TSCATQIITF ESFKENLKDF LLVIPFDCWE PVQE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Granulocyte-macrophage colony-stimulating factor (CSF2)