Major prion protein (PRNP)

About Major prion protein

Major prion protein (PRNP) is a protein from Homo sapiens identified by UniProt accession P04156, 253 residues long. MolForge cross-references it against 0 known binders and 718 disease associations.

Target properties

Protein name	Major prion protein
UniProt accession	P04156
Gene	PRNP
Organism	Homo sapiens
Length	253 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (8)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (718)

Diseases linked to this target (Open Targets).

Gerstmann-Straussler-Scheinker syndrome · score 0.81
Huntington disease-like 1 · score 0.77
inherited Creutzfeldt-Jakob disease · score 0.76
prion disease · score 0.70
Creutzfeldt Jacob Disease · score 0.68
cerebral amyloid angiopathy · score 0.67
fatal familial insomnia · score 0.67
neurodegenerative disease · score 0.50
genetic disorder · score 0.48
inherited prion disease · score 0.47

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P04156-F1	alphafold	PREDICTED	64.16	—

Amino-acid sequence (253 residues)

MANLGCWMLV LFVATWSDLG LCKKRPKPGG WNTGGSRYPG QGSPGGNRYP PQGGGGWGQP HGGGWGQPHG GGWGQPHGGG WGQPHGGGWG QGGGTHSQWN KPSKPKTNMK HMAGAAAAGA VVGGLGGYML GSAMSRPIIH FGSDYEDRYY RENMHRYPNQ VYYRPMDEYS NQNNFVHDCV NITIKQHTVT TTTKGENFTE TDVKMMERVV EQMCITQYER ESQAYYQRGS SMVLFSSPPV ILLISFLIFL IVG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards