Phosphatidylcholine-sterol acyltransferase (LCAT)

About Phosphatidylcholine-sterol acyltransferase

Phosphatidylcholine-sterol acyltransferase (LCAT) is a protein from Homo sapiens identified by UniProt accession P04180, 440 residues long. MolForge cross-references it against 0 known binders and 450 disease associations.

Target properties

Protein name	Phosphatidylcholine-sterol acyltransferase
UniProt accession	P04180
Gene	LCAT
Organism	Homo sapiens
Length	440 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (450)

Diseases linked to this target (Open Targets).

Fish-eye disease · score 0.82
Norum disease · score 0.80
Familial LCAT deficiency · score 0.76
high density lipoprotein cholesterol measurement · score 0.68
fish eye disease · score 0.67
LCAT deficiency · score 0.66
lipoprotein measurement · score 0.59
phospholipids:total lipids ratio · score 0.59
cholesteryl ester measurement · score 0.57
cholesterol to total lipids in medium HDL percentage · score 0.57

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P04180-F1	alphafold	PREDICTED	86.78	—

Amino-acid sequence (440 residues)

MGPPGSPWQW VTLLLGLLLP PAAPFWLLNV LFPPHTTPKA ELSNHTRPVI LVPGCLGNQL EAKLDKPDVV NWMCYRKTED FFTIWLDLNM FLPLGVDCWI DNTRVVYNRS SGLVSNAPGV QIRVPGFGKT YSVEYLDSSK LAGYLHTLVQ NLVNNGYVRD ETVRAAPYDW RLEPGQQEEY YRKLAGLVEE MHAAYGKPVF LIGHSLGCLH LLYFLLRQPQ AWKDRFIDGF ISLGAPWGGS IKPMLVLASG DNQGIPIMSS IKLKEEQRIT TTSPWMFPSR MAWPEDHVFI STPSFNYTGR DFQRFFADLH FEEGWYMWLQ SRDLLAGLPA PGVEVYCLYG VGLPTPRTYI YDHGFPYTDP VGVLYEDGDD TVATRSTELC GLWQGRQPQP VHLLPLHGIQ HLNMVFSNLT LEHINAILLG AYRQGPPASP TASPEPPPPE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards