About Histidine-rich glycoprotein
Histidine-rich glycoprotein (HRG) is a protein
from Homo sapiens identified by UniProt accession
P04196, 525 residues long.
MolForge cross-references it against 0 known binders and
117 disease associations.
Target properties
| Protein name | Histidine-rich glycoprotein |
|---|
| UniProt accession | P04196 |
|---|
| Gene | HRG |
|---|
| Organism | Homo sapiens |
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| Length | 525 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (117)
Diseases linked to this target (Open Targets).
- hereditary thrombophilia due to congenital histidine-rich (poly-L) glycoprotein deficiency · score 0.71
- blood protein measurement · score 0.48
- CD27 antigen measurement · score 0.40
- protein measurement · score 0.39
- dual specificity mitogen-activated protein kinase kinase 4 measurement · score 0.37
- partial thromboplastin time · score 0.37
- histidine-rich glycoprotein measurement · score 0.36
- electrocardiography · score 0.33
- persulfide dioxygenase ETHE1, mitochondrial measurement · score 0.30
- aspartate aminotransferase measurement · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P04196-F1 | alphafold | PREDICTED | 64.82 | — |
Amino-acid sequence (525 residues)
MKALIAALLL ITLQYSCAVS PTDCSAVEPE AEKALDLINK RRRDGYLFQL LRIADAHLDR VENTTVYYLV LDVQESDCSV LSRKYWNDCE PPDSRRPSEI VIGQCKVIAT RHSHESQDLR VIDFNCTTSS VSSALANTKD SPVLIDFFED TERYRKQANK ALEKYKEEND DFASFRVDRI ERVARVRGGE GTGYFVDFSV RNCPRHHFPR HPNVFGFCRA DLFYDVEALD LESPKNLVIN CEVFDPQEHE NINGVPPHLG HPFHWGGHER SSTTKPPFKP HGSRDHHHPH KPHEHGPPPP PDERDHSHGP PLPQGPPPLL PMSCSSCQHA TFGTNGAQRH SHNNNSSDLH PHKHHSHEQH PHGHHPHAHH PHEHDTHRQH PHGHHPHGHH PHGHHPHGHH PHGHHPHCHD FQDYGPCDPP PHNQGHCCHG HGPPPGHLRR RGPGKGPRPF HCRQIGSVYR LPPLRKGEVL PLPEANFPSF PLPHHKHPLK PDNQPFPQSV SESCPGKFKS GFPQVSMFFT HTFPK
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