N-myc proto-oncogene protein (MYCN)

About N-myc proto-oncogene protein

N-myc proto-oncogene protein (MYCN) is a protein from Homo sapiens identified by UniProt accession P04198, 464 residues long. MolForge cross-references it against 0 known binders and 503 disease associations.

Target properties

Protein name	N-myc proto-oncogene protein
UniProt accession	P04198
Gene	MYCN
Organism	Homo sapiens
Length	464 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (503)

Diseases linked to this target (Open Targets).

Feingold syndrome type 1 · score 0.82
neurodegenerative disease · score 0.53
genetic disorder · score 0.52
megalencephaly-polydactyly syndrome · score 0.52
basal cell carcinoma · score 0.47
lymphocyte count · score 0.42
body height · score 0.40
appendicular lean mass · score 0.39
melanoma · score 0.38
skin basal cell carcinoma · score 0.38

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P04198-F1	alphafold	PREDICTED	60.15	—

Amino-acid sequence (464 residues)

MPSCSTSTMP GMICKNPDLE FDSLQPCFYP DEDDFYFGGP DSTPPGEDIW KKFELLPTPP LSPSRGFAEH SSEPPSWVTE MLLENELWGS PAEEDAFGLG GLGGLTPNPV ILQDCMWSGF SAREKLERAV SEKLQHGRGP PTAGSTAQSP GAGAASPAGR GHGGAAGAGR AGAALPAELA HPAAECVDPA VVFPFPVNKR EPAPVPAAPA SAPAAGPAVA SGAGIAAPAG APGVAPPRPG GRQTSGGDHK ALSTSGEDTL SDSDDEDDEE EDEEEEIDVV TVEKRRSSSN TKAVTTFTIT VRPKNAALGP GRAQSSELIL KRCLPIHQQH NYAAPSPYVE SEDAPPQKKI KSEASPRPLK SVIPPKAKSL SPRNSDSEDS ERRRNHNILE RQRRNDLRSS FLTLRDHVPE LVKNEKAAKV VILKKATEYV HSLQAEEHQL LLEKEKLQAR QQQLLKKIEH ARTC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards