HLA class II histocompatibility antigen gamma chain (CD74)

About HLA class II histocompatibility antigen gamma chain

HLA class II histocompatibility antigen gamma chain (CD74) is a protein from Homo sapiens identified by UniProt accession P04233, 296 residues long. MolForge cross-references it against 0 known binders and 581 disease associations.

Target properties

Protein name	HLA class II histocompatibility antigen gamma chain
UniProt accession	P04233
Gene	CD74
Organism	Homo sapiens
Length	296 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P04233-F1	alphafold	PREDICTED	69.93	—

Amino-acid sequence (296 residues)

MHRRRSRSCR EDQKPVMDDQ RDLISNNEQL PMLGRRPGAP ESKCSRGALY TGFSILVTLL LAGQATTAYF LYQQQGRLDK LTVTSQNLQL ENLRMKLPKP PKPVSKMRMA TPLLMQALPM GALPQGPMQN ATKYGNMTED HVMHLLQNAD PLKVYPPLKG SFPENLRHLK NTMETIDWKV FESWMHHWLL FEMSRHSLEQ KPTDAPPKVL TKCQEEVSHI PAVHPGSFRP KCDENGNYLP LQCYGSIGYC WCVFPNGTEV PNTRSRGHHN CSESLELEDP SSGLGVTKQD LGPVPM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards