T-cell surface glycoprotein CD3 delta chain (CD3D)

About T-cell surface glycoprotein CD3 delta chain

T-cell surface glycoprotein CD3 delta chain (CD3D) is a protein from Homo sapiens identified by UniProt accession P04234, 171 residues long. MolForge cross-references it against 0 known binders and 211 disease associations.

Target properties

Protein name	T-cell surface glycoprotein CD3 delta chain
UniProt accession	P04234
Gene	CD3D
Organism	Homo sapiens
Length	171 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (211)

Diseases linked to this target (Open Targets).

immunodeficiency 19 · score 0.74
multiple myeloma · score 0.58
follicular lymphoma · score 0.54
diffuse large B-cell lymphoma · score 0.54
acute lymphoblastic leukemia · score 0.52
lymphoid leukemia · score 0.51
neoplasm · score 0.49
immunodeficiency 104 · score 0.46
T-B+ severe combined immunodeficiency · score 0.46
leukemia · score 0.45

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P04234-F1	alphafold	PREDICTED	77.67	—

Amino-acid sequence (171 residues)

MEHSTFLSGL VLATLLSQVS PFKIPIEELE DRVFVNCNTS ITWVEGTVGT LLSDITRLDL GKRILDPRGI YRCNGTDIYK DKESTVQVHY RMCQSCVELD PATVAGIIVT DVIATLLLAL GVFCFAGHET GRLSGAADTQ ALLRNDQVYQ PLRDRDDAQY SHLGGNWARN K

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards