About Keratin, type II cytoskeletal 1
Keratin, type II cytoskeletal 1 (KRT1) is a protein
from Homo sapiens identified by UniProt accession
P04264, 644 residues long.
MolForge cross-references it against 0 known binders and
429 disease associations.
Target properties
| Protein name | Keratin, type II cytoskeletal 1 |
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| UniProt accession | P04264 |
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| Gene | KRT1 |
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| Organism | Homo sapiens |
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| Length | 644 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (429)
Diseases linked to this target (Open Targets).
- epidermolytic hyperkeratosis 1 · score 0.74
- epidermolytic ichthyosis · score 0.69
- ichthyosis hystrix of Curth-Macklin · score 0.68
- diffuse nonepidermolytic palmoplantar keratoderma · score 0.67
- Non-epidermolytic palmoplantar keratoderma · score 0.58
- epidermolytic palmoplantar keratoderma, 1 · score 0.55
- annular epidermolytic ichthyosis · score 0.52
- ichthyosis, annular epidermolytic 1 · score 0.50
- keratosis palmoplantaris striata 3 · score 0.49
- Nonepidermolytic palmoplantar hyperkeratosis · score 0.49
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P04264-F1 | alphafold | PREDICTED | 63.05 | — |
Amino-acid sequence (644 residues)
MSRQFSSRSG YRSGGGFSSG SAGIINYQRR TTSSSTRRSG GGGGRFSSCG GGGGSFGAGG GFGSRSLVNL GGSKSISISV ARGGGRGSGF GGGYGGGGFG GGGFGGGGFG GGGIGGGGFG GFGSGGGGFG GGGFGGGGYG GGYGPVCPPG GIQEVTINQS LLQPLNVEID PEIQKVKSRE REQIKSLNNQ FASFIDKVRF LEQQNQVLQT KWELLQQVDT STRTHNLEPY FESFINNLRR RVDQLKSDQS RLDSELKNMQ DMVEDYRNKY EDEINKRTNA ENEFVTIKKD VDGAYMTKVD LQAKLDNLQQ EIDFLTALYQ AELSQMQTQI SETNVILSMD NNRSLDLDSI IAEVKAQYED IAQKSKAEAE SLYQSKYEEL QITAGRHGDS VRNSKIEISE LNRVIQRLRS EIDNVKKQIS NLQQSISDAE QRGENALKDA KNKLNDLEDA LQQAKEDLAR LLRDYQELMN TKLALDLEIA TYRTLLEGEE SRMSGECAPN VSVSVSTSHT TISGGGSRGG GGGGYGSGGS SYGSGGGSYG SGGGGGGGRG SYGSGGSSYG SGGGSYGSGG GGGGHGSYGS GSSSGGYRGG SGGGGGGSSG GRGSGGGSSG GSIGGRGSSS GGVKSSGGSS SVKFVSTTYS GVTR
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