About Semenogelin-1
Semenogelin-1 (SEMG1) is a protein
from Homo sapiens identified by UniProt accession
P04279, 462 residues long.
MolForge cross-references it against 0 known binders and
78 disease associations.
Target properties
| Protein name | Semenogelin-1 |
|---|
| UniProt accession | P04279 |
|---|
| Gene | SEMG1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 462 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (78)
Diseases linked to this target (Open Targets).
- AL amyloidosis · score 0.46
- blood protein measurement · score 0.19
- lung adenocarcinoma · score 0.18
- glioblastoma multiforme · score 0.17
- squamous cell lung carcinoma · score 0.14
- head and neck squamous cell carcinoma · score 0.12
- breast adenocarcinoma · score 0.10
- azoospermia · score 0.07
- male infertility with teratozoospermia due to single gene mutation · score 0.06
- elafin measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P04279-F1 | alphafold | PREDICTED | 32.80 | — |
Amino-acid sequence (462 residues)
MKPNIIFVLS LLLILEKQAA VMGQKGGSKG RLPSEFSQFP HGQKGQHYSG QKGKQQTESK GSFSIQYTYH VDANDHDQSR KSQQYDLNAL HKTTKSQRHL GGSQQLLHNK QEGRDHDKSK GHFHRVVIHH KGGKAHRGTQ NPSQDQGNSP SGKGISSQYS NTEERLWVHG LSKEQTSVSG AQKGRKQGGS QSSYVLQTEE LVANKQQRET KNSHQNKGHY QNVVEVREEH SSKVQTSLCP AHQDKLQHGS KDIFSTQDEL LVYNKNQHQT KNLNQDQQHG RKANKISYQS SSTEERRLHY GENGVQKDVS QSSIYSQTEE KAQGKSQKQI TIPSQEQEHS QKANKISYQS SSTEERRLHY GENGVQKDVS QRSIYSQTEK LVAGKSQIQA PNPKQEPWHG ENAKGESGQS TNREQDLLSH EQKGRHQHGS HGGLDIVIIE QEDDSDRHLA QHLNNDRNPL FT
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