Tubulin beta-4A chain (TUBB4A)

About Tubulin beta-4A chain

Tubulin beta-4A chain (TUBB4A) is a protein from Homo sapiens identified by UniProt accession P04350, 444 residues long. MolForge cross-references it against 0 known binders and 831 disease associations.

Target properties

Protein name	Tubulin beta-4A chain
UniProt accession	P04350
Gene	TUBB4A
Organism	Homo sapiens
Length	444 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (831)

Diseases linked to this target (Open Targets).

Primary dystonia, DYT4 type · score 0.79
hypomyelinating leukodystrophy 6 · score 0.72
Hypomyelination with atrophy of basal ganglia and cerebellum · score 0.72
torsion dystonia 4 · score 0.71
neoplasm · score 0.61
head and neck squamous cell carcinoma · score 0.61
breast cancer · score 0.61
non-small cell lung carcinoma · score 0.61
breast carcinoma · score 0.60
ovarian cancer · score 0.60

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P04350-F1	alphafold	PREDICTED	92.17	—

Amino-acid sequence (444 residues)

MREIVHLQAG QCGNQIGAKF WEVISDEHGI DPTGTYHGDS DLQLERINVY YNEATGGNYV PRAVLVDLEP GTMDSVRSGP FGQIFRPDNF VFGQSGAGNN WAKGHYTEGA ELVDAVLDVV RKEAESCDCL QGFQLTHSLG GGTGSGMGTL LISKIREEFP DRIMNTFSVV PSPKVSDTVV EPYNATLSVH QLVENTDETY CIDNEALYDI CFRTLKLTTP TYGDLNHLVS ATMSGVTTCL RFPGQLNADL RKLAVNMVPF PRLHFFMPGF APLTSRGSQQ YRALTVPELT QQMFDAKNMM AACDPRHGRY LTVAAVFRGR MSMKEVDEQM LSVQSKNSSY FVEWIPNNVK TAVCDIPPRG LKMAATFIGN STAIQELFKR ISEQFTAMFR RKAFLHWYTG EGMDEMEFTE AESNMNDLVS EYQQYQDATA EEGEFEEEAE EEVA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards