Argininosuccinate lyase (ASL)

About Argininosuccinate lyase

Argininosuccinate lyase (ASL) is a protein from Homo sapiens identified by UniProt accession P04424, 464 residues long. MolForge cross-references it against 0 known binders and 103 disease associations.

Target properties

Protein name	Argininosuccinate lyase
UniProt accession	P04424
Gene	ASL
Organism	Homo sapiens
Length	464 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (103)

Diseases linked to this target (Open Targets).

argininosuccinic aciduria · score 0.87
Neurodevelopmental disorder · score 0.44
genetic disorder · score 0.41
blood protein measurement · score 0.38
Tremor · score 0.37
Ataxia · score 0.37
Dystonia · score 0.37
Seizure · score 0.37
Congenital myasthenic syndromes · score 0.34
lung adenocarcinoma · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P04424-F1	alphafold	PREDICTED	96.31	—

Amino-acid sequence (464 residues)

MASESGKLWG GRFVGAVDPI MEKFNASIAY DRHLWEVDVQ GSKAYSRGLE KAGLLTKAEM DQILHGLDKV AEEWAQGTFK LNSNDEDIHT ANERRLKELI GATAGKLHTG RSRNDQVVTD LRLWMRQTCS TLSGLLWELI RTMVDRAEAE RDVLFPGYTH LQRAQPIRWS HWILSHAVAL TRDSERLLEV RKRINVLPLG SGAIAGNPLG VDRELLRAEL NFGAITLNSM DATSERDFVA EFLFWASLCM THLSRMAEDL ILYCTKEFSF VQLSDAYSTG SSLMPQKKNP DSLELIRSKA GRVFGRCAGL LMTLKGLPST YNKDLQEDKE AVFEVSDTMS AVLQVATGVI STLQIHQENM GQALSPDMLA TDLAYYLVRK GMPFRQAHEA SGKAVFMAET KGVALNQLSL QELQTISPLF SGDVICVWDY GHSVEQYGAL GGTARSSVDW QIRQVRALLQ AQQA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards