Immunoglobulin kappa variable 3-11 (IGKV3-11)

About Immunoglobulin kappa variable 3-11

Immunoglobulin kappa variable 3-11 (IGKV3-11) is a protein from Homo sapiens identified by UniProt accession P04433, 115 residues long. MolForge cross-references it against 0 known binders and 13 disease associations.

Target properties

Protein name	Immunoglobulin kappa variable 3-11
UniProt accession	P04433
Gene	IGKV3-11
Organism	Homo sapiens
Length	115 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	LOW
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (13)

Diseases linked to this target (Open Targets).

cutaneous Leishmaniasis · score 0.59
Barrett's esophagus · score 0.07
sebaceous of Jadassohn nevus · score 0.05
squamous cell carcinoma · score 0.05
esophageal adenocarcinoma · score 0.05
Crohn's disease · score 0.02
cutaneous lupus erythematosus · score 0.02
ulcerative colitis · score 0.01
esophageal squamous cell carcinoma · score 0.01
idiopathic pulmonary fibrosis · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P04433-F1	alphafold	PREDICTED	89.61	—

Amino-acid sequence (115 residues)

MEAPAQLLFL LLLWLPDTTG EIVLTQSPAT LSLSPGERAT LSCRASQSVS SYLAWYQQKP GQAPRLLIYD ASNRATGIPA RFSGSGSGTD FTLTISSLEP EDFAVYYCQQ RSNWP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards