About HLA class I histocompatibility antigen, A alpha chain
HLA class I histocompatibility antigen, A alpha chain (HLA-A) is a protein
from Homo sapiens identified by UniProt accession
P04439, 365 residues long.
MolForge cross-references it against 0 known binders and
887 disease associations.
Target properties
| Protein name | HLA class I histocompatibility antigen, A alpha chain |
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| UniProt accession | P04439 |
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| Gene | HLA-A |
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| Organism | Homo sapiens |
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| Length | 365 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (5)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (887)
Diseases linked to this target (Open Targets).
- diffuse large B-cell lymphoma · score 0.55
- HIV infection · score 0.53
- cervical squamous cell carcinoma · score 0.53
- COVID-19 · score 0.48
- squamous cell lung carcinoma · score 0.43
- head and neck squamous cell carcinoma · score 0.43
- nasopharyngeal neoplasm · score 0.42
- blood protein measurement · score 0.38
- melanocytic neoplasm · score 0.37
- spitz nevus · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P04439-F1 | alphafold | PREDICTED | 87.13 | — |
Amino-acid sequence (365 residues)
MAVMAPRTLL LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDQETRN VKAQSQTDRV DLGTLRGYYN QSEAGSHTIQ IMYGCDVGSD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITKRK WEAAHEAEQL RAYLDGTCVE WLRRYLENGK ETLQRTDPPK THMTHHPISD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PKPLTLRWEL SSQPTIPIVG IIAGLVLLGA VITGAVVAAV MWRRKSSDRK GGSYTQAASS DSAQGSDVSL TACKV
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