Sperm protamine P1 (PRM1)

About Sperm protamine P1

Sperm protamine P1 (PRM1) is a protein from Homo sapiens identified by UniProt accession P04553, 51 residues long. MolForge cross-references it against 0 known binders and 167 disease associations.

Target properties

Protein name	Sperm protamine P1
UniProt accession	P04553
Gene	PRM1
Organism	Homo sapiens
Length	51 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (167)

Diseases linked to this target (Open Targets).

drug dependence · score 0.12
azoospermia · score 0.11
mean corpuscular volume · score 0.10
Hepatitis · score 0.10
high density lipoprotein cholesterol measurement · score 0.10
eosinophil count · score 0.09
male infertility with teratozoospermia due to single gene mutation · score 0.09
cystatin C measurement · score 0.09
gut microbiome measurement · score 0.09
multiple sclerosis · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P04553-F1	alphafold	PREDICTED	54.13	—

Amino-acid sequence (51 residues)

MARYRCCRSQ SRSRYYRQRQ RSRRRRRRSC QTRRRAMRCC RPRYRPRCRR H

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards