Protamine-2 (PRM2)

About Protamine-2

Protamine-2 (PRM2) is a protein from Homo sapiens identified by UniProt accession P04554, 102 residues long. MolForge cross-references it against 0 known binders and 187 disease associations.

Target properties

Protein name	Protamine-2
UniProt accession	P04554
Gene	PRM2
Organism	Homo sapiens
Length	102 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (187)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.27
azoospermia · score 0.11
male infertility with teratozoospermia due to single gene mutation · score 0.10
drug dependence · score 0.10
Hepatitis · score 0.09
spermatogenic failure 72 · score 0.09
spermatogenic failure 18 · score 0.09
spermatogenic failure 46 · score 0.09
spermatogenic failure 27 · score 0.09
spermatogenic failure 65 · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P04554-F1	alphafold	PREDICTED	53.82	—

Amino-acid sequence (102 residues)

MVRYRVRSLS ERSHEVYRQQ LHGQEQGHHG QEEQGLSPEH VEVYERTHGQ SHYRRRHCSR RRLHRIHRRQ HRSCRRRKRR SCRHRRRHRR GCRTRKRTCR RH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards