About Calpain small subunit 1
Calpain small subunit 1 (CAPNS1) is a protein
from Homo sapiens identified by UniProt accession
P04632, 268 residues long.
MolForge cross-references it against 0 known binders and
92 disease associations.
Target properties
| Protein name | Calpain small subunit 1 |
|---|
| UniProt accession | P04632 |
|---|
| Gene | CAPNS1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 268 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (92)
Diseases linked to this target (Open Targets).
- Alzheimer disease · score 0.37
- neurodegenerative disease · score 0.28
- breast adenocarcinoma · score 0.26
- glioblastoma multiforme · score 0.23
- prostate adenocarcinoma · score 0.21
- head and neck squamous cell carcinoma · score 0.18
- neoplasm · score 0.09
- esophageal squamous cell carcinoma · score 0.08
- intrahepatic cholangiocarcinoma · score 0.08
- type 2 diabetes mellitus · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P04632-F1 | alphafold | PREDICTED | 75.26 | — |
Amino-acid sequence (268 residues)
MFLVNSFLKG GGGGGGGGGG LGGGLGNVLG GLISGAGGGG GGGGGGGGGG GGGGGGTAMR ILGGVISAIS EAAAQYNPEP PPPRTHYSNI EANESEEVRQ FRRLFAQLAG DDMEVSATEL MNILNKVVTR HPDLKTDGFG IDTCRSMVAV MDSDTTGKLG FEEFKYLWNN IKRWQAIYKQ FDTDRSGTIC SSELPGAFEA AGFHLNEHLY NMIIRRYSDE SGNMDFDNFI SCLVRLDAMF RAFKSLDKDG TGQIQVNIQE WLQLTMYS
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