Metallothionein-1A (MT1A)

About Metallothionein-1A

Metallothionein-1A (MT1A) is a protein from Homo sapiens identified by UniProt accession P04731, 61 residues long. MolForge cross-references it against 0 known binders and 128 disease associations.

Target properties

Protein name	Metallothionein-1A
UniProt accession	P04731
Gene	MT1A
Organism	Homo sapiens
Length	61 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (128)

Diseases linked to this target (Open Targets).

hepatocellular carcinoma · score 0.10
breast carcinoma · score 0.08
schizophrenia · score 0.05
neoplasm · score 0.04
cancer · score 0.03
non-alcoholic steatohepatitis · score 0.03
age-related macular degeneration · score 0.03
glioblastoma · score 0.03
melanoma · score 0.03
oral squamous cell carcinoma · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P04731-F1	alphafold	PREDICTED	78.99	—

Amino-acid sequence (61 residues)

MDPNCSCATG GSCTCTGSCK CKECKCTSCK KSCCSCCPMS CAKCAQGCIC KGASEKCSCC A

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards