About Pancreatic alpha-amylase
Pancreatic alpha-amylase (AMY2A) is a protein
from Homo sapiens identified by UniProt accession
P04746, 511 residues long.
MolForge cross-references it against 0 known binders and
49 disease associations.
Target properties
| Protein name | Pancreatic alpha-amylase |
|---|
| UniProt accession | P04746 |
|---|
| Gene | AMY2A |
|---|
| Organism | Homo sapiens |
|---|
| Length | 511 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (49)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.60
- diabetes mellitus · score 0.55
- chronic hepatitis C virus infection · score 0.37
- neurodegenerative disease · score 0.33
- atherosclerosis · score 0.26
- metabolic disease · score 0.26
- metabolic syndrome · score 0.26
- hypertension · score 0.26
- coronary artery disease · score 0.26
- gestational diabetes · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P04746-F1 | alphafold | PREDICTED | 96.72 | — |
Amino-acid sequence (511 residues)
MKFFLLLFTI GFCWAQYSPN TQQGRTSIVH LFEWRWVDIA LECERYLAPK GFGGVQVSPP NENVAIYNPF RPWWERYQPV SYKLCTRSGN EDEFRNMVTR CNNVGVRIYV DAVINHMCGN AVSAGTSSTC GSYFNPGSRD FPAVPYSGWD FNDGKCKTGS GDIENYNDAT QVRDCRLTGL LDLALEKDYV RSKIAEYMNH LIDIGVAGFR LDASKHMWPG DIKAILDKLH NLNSNWFPAG SKPFIYQEVI DLGGEPIKSS DYFGNGRVTE FKYGAKLGTV IRKWNGEKMS YLKNWGEGWG FVPSDRALVF VDNHDNQRGH GAGGASILTF WDARLYKMAV GFMLAHPYGF TRVMSSYRWP RQFQNGNDVN DWVGPPNNNG VIKEVTINPD TTCGNDWVCE HRWRQIRNMV IFRNVVDGQP FTNWYDNGSN QVAFGRGNRG FIVFNNDDWS FSLTLQTGLP AGTYCDVISG DKINGNCTGI KIYVSDDGKA HFSISNSAED PFIAIHAESK L
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