Heat shock protein beta-1 (HSPB1)

About Heat shock protein beta-1

Heat shock protein beta-1 (HSPB1) is a protein from Homo sapiens identified by UniProt accession P04792, 205 residues long. MolForge cross-references it against 0 known binders and 424 disease associations.

Target properties

Protein name	Heat shock protein beta-1
UniProt accession	P04792
Gene	HSPB1
Organism	Homo sapiens
Length	205 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (424)

Diseases linked to this target (Open Targets).

Charcot-Marie-Tooth disease axonal type 2F · score 0.81
neuronopathy, distal hereditary motor, type 2B · score 0.81
Autosomal dominant Charcot-Marie-Tooth disease type 2F · score 0.77
Charcot-Marie-Tooth disease · score 0.58
genetic disorder · score 0.51
distal hereditary motor neuropathy type 2 · score 0.46
blood protein measurement · score 0.37
heat shock 27 kDa protein measurement · score 0.24
Charcot-Marie-Tooth disease type 4 · score 0.14
distal hereditary motor neuropathy · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P04792-F1	alphafold	PREDICTED	68.85	—

Amino-acid sequence (205 residues)

MTERRVPFSL LRGPSWDPFR DWYPHSRLFD QAFGLPRLPE EWSQWLGGSS WPGYVRPLPP AAIESPAVAA PAYSRALSRQ LSSGVSEIRH TADRWRVSLD VNHFAPDELT VKTKDGVVEI TGKHEERQDE HGYISRCFTR KYTLPPGVDP TQVSSSLSPE GTLTVEAPMP KLATQSNEIT IPVTFESRAQ LGGPEAAKSD ETAAK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards