About NADPH oxidase 2
NADPH oxidase 2 (CYBB) is a protein
from Homo sapiens identified by UniProt accession
P04839, 570 residues long.
MolForge cross-references it against 0 known binders and
815 disease associations.
Target properties
| Protein name | NADPH oxidase 2 |
|---|
| UniProt accession | P04839 |
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| Gene | CYBB |
|---|
| Organism | Homo sapiens |
|---|
| Length | 570 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (815)
Diseases linked to this target (Open Targets).
- chronic granulomatous disease · score 0.71
- neurodegenerative disease · score 0.35
- breast adenocarcinoma · score 0.25
- discoid lupus erythematosus · score 0.18
- genetic disorder · score 0.18
- low grade glioma · score 0.17
- inflammatory bowel disease · score 0.17
- multiple myeloma · score 0.13
- acute myeloid leukemia · score 0.13
- primary ciliary dyskinesia · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P04839-F1 | alphafold | PREDICTED | 90.23 | — |
Amino-acid sequence (570 residues)
MGNWAVNEGL SIFVILVWLG LNVFLFVWYY RVYDIPPKFF YTRKLLGSAL ALARAPAACL NFNCMLILLP VCRNLLSFLR GSSACCSTRV RRQLDRNLTF HKMVAWMIAL HSAIHTIAHL FNVEWCVNAR VNNSDPYSVA LSELGDRQNE SYLNFARKRI KNPEGGLYLA VTLLAGITGV VITLCLILII TSSTKTIRRS YFEVFWYTHH LFVIFFIGLA IHGAERIVRG QTAESLAVHN ITVCEQKISE WGKIKECPIP QFAGNPPMTW KWIVGPMFLY LCERLVRFWR SQQKVVITKV VTHPFKTIEL QMKKKGFKME VGQYIFVKCP KVSKLEWHPF TLTSAPEEDF FSIHIRIVGD WTEGLFNACG CDKQEFQDAW KLPKIAVDGP FGTASEDVFS YEVVMLVGAG IGVTPFASIL KSVWYKYCNN ATNLKLKKIY FYWLCRDTHA FEWFADLLQL LESQMQERNN AGFLSYNIYL TGWDESQANH FAVHHDEEKD VITGLKQKTL YGRPNWDNEF KTIASQHPNT RIGVFLCGPE ALAETLSKQS ISNSESGPRG VHFIFNKENF
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