About Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (RPN1) is a protein
from Homo sapiens identified by UniProt accession
P04843, 607 residues long.
MolForge cross-references it against 0 known binders and
157 disease associations.
Target properties
| Protein name | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 |
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| UniProt accession | P04843 |
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| Gene | RPN1 |
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| Organism | Homo sapiens |
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| Length | 607 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (157)
Diseases linked to this target (Open Targets).
- COVID-19 · score 0.37
- monocyte count · score 0.35
- eosinophil count · score 0.34
- monocyte percentage of leukocytes · score 0.33
- neutrophil count · score 0.33
- basophil count · score 0.32
- mean corpuscular volume · score 0.32
- leukocyte count · score 0.31
- eosinophil percentage of leukocytes · score 0.29
- mean platelet volume · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P04843-F1 | alphafold | PREDICTED | 90.12 | — |
Amino-acid sequence (607 residues)
MEAPAAGLFL LLLLGTWAPA PGSASSEAPP LINEDVKRTV DLSSHLAKVT AEVVLAHLGG GSTSRATSFL LALEPELEAR LAHLGVQVKG EDEEENNLEV RETKIKGKSG RFFTVKLPVA LDPGAKISVI VETVYTHVLH PYPTQITQSE KQFVVFEGNH YFYSPYPTKT QTMRVKLASR NVESYTKLGN PTRSEDLLDY GPFRDVPAYS QDTFKVHYEN NSPFLTITSM TRVIEVSHWG NIAVEENVDL KHTGAVLKGP FSRYDYQRQP DSGISSIRSF KTILPAAAQD VYYRDEIGNV STSHLLILDD SVEMEIRPRF PLFGGWKTHY IVGYNLPSYE YLYNLGDQYA LKMRFVDHVF DEQVIDSLTV KIILPEGAKN IEIDSPYEIS RAPDELHYTY LDTFGRPVIV AYKKNLVEQH IQDIVVHYTF NKVLMLQEPL LVVAAFYILF FTVIIYVRLD FSITKDPAAE ARMKVACITE QVLTLVNKRI GLYRHFDETV NRYKQSRDIS TLNSGKKSLE TEHKALTSEI ALLQSRLKTE GSDLCDRVSE MQKLDAQVKE LVLKSAVEAE RLVAGKLKKD TYIENEKLIS GKRQELVTKI DHILDAL
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