About Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (RPN2) is a protein
from Homo sapiens identified by UniProt accession
P04844, 631 residues long.
MolForge cross-references it against 0 known binders and
53 disease associations.
Target properties
| Protein name | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 |
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| UniProt accession | P04844 |
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| Gene | RPN2 |
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| Organism | Homo sapiens |
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| Length | 631 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (53)
Diseases linked to this target (Open Targets).
- COVID-19 · score 0.37
- body height · score 0.20
- congenital disorder of glycosylation · score 0.19
- appendicular lean mass · score 0.17
- lean body mass · score 0.15
- body weight · score 0.13
- endometrial cancer · score 0.11
- body mass index · score 0.10
- glioblastoma multiforme · score 0.09
- non-small cell lung carcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P04844-F1 | alphafold | PREDICTED | 89.25 | — |
Amino-acid sequence (631 residues)
MAPPGSSTVF LLALTIIAST WALTPTHYLT KHDVERLKAS LDRPFTNLES AFYSIVGLSS LGAQVPDAKK ACTYIRSNLD PSNVDSLFYA AQASQALSGC EISISNETKD LLLAAVSEDS SVTQIYHAVA ALSGFGLPLA SQEALSALTA RLSKEETVLA TVQALQTASH LSQQADLRSI VEEIEDLVAR LDELGGVYLQ FEEGLETTAL FVAATYKLMD HVGTEPSIKE DQVIQLMNAI FSKKNFESLS EAFSVASAAA VLSHNRYHVP VVVVPEGSAS DTHEQAILRL QVTNVLSQPL TQATVKLEHA KSVASRATVL QKTSFTPVGD VFELNFMNVK FSSGYYDFLV EVEGDNRYIA NTVELRVKIS TEVGITNVDL STVDKDQSIA PKTTRVTYPA KAKGTFIADS HQNFALFFQL VDVNTGAELT PHQTFVRLHN QKTGQEVVFV AEPDNKNVYK FELDTSERKI EFDSASGTYT LYLIIGDATL KNPILWNVAD VVIKFPEEEA PSTVLSQNLF TPKQEIQHLF REPEKRPPTV VSNTFTALIL SPLLLLFALW IRIGANVSNF TFAPSTIIFH LGHAAMLGLM YVYWTQLNMF QTLKYLAILG SVTFLAGNRM LAQQAVKRTA H
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