Histone H2A type 1-B/E (H2AC4)

About Histone H2A type 1-B/E

Histone H2A type 1-B/E (H2AC4) is a protein from Homo sapiens identified by UniProt accession P04908, 130 residues long. MolForge cross-references it against 0 known binders and 114 disease associations.

Target properties

Protein name	Histone H2A type 1-B/E
UniProt accession	P04908
Gene	H2AC4
Organism	Homo sapiens
Length	130 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (114)

Diseases linked to this target (Open Targets).

viral disease · score 0.50
infectious disease · score 0.50
breast carcinoma · score 0.39
cancer · score 0.37
melanoma · score 0.37
Red cell distribution width · score 0.19
mean corpuscular hemoglobin concentration · score 0.17
mean corpuscular volume · score 0.15
hemoglobin measurement · score 0.13
urate measurement · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P04908-F1	alphafold	PREDICTED	90.77	—

Amino-acid sequence (130 residues)

MSGRGKQGGK ARAKAKTRSS RAGLQFPVGR VHRLLRKGNY SERVGAGAPV YLAAVLEYLT AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGR VTIAQGGVLP NIQAVLLPKK TESHHKAKGK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards