Glycophorin-C (GYPC)

About Glycophorin-C

Glycophorin-C (GYPC) is a protein from Homo sapiens identified by UniProt accession P04921, 128 residues long. MolForge cross-references it against 0 known binders and 150 disease associations.

Target properties

Protein name	Glycophorin-C
UniProt accession	P04921
Gene	GYPC
Organism	Homo sapiens
Length	128 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (150)

Diseases linked to this target (Open Targets).

mean corpuscular hemoglobin concentration · score 0.46
reticulocyte count · score 0.45
reticulocyte measurement · score 0.39
hemoglobin measurement · score 0.39
erythrocyte count · score 0.39
malaria · score 0.37
hereditary elliptocytosis · score 0.37
atrial fibrillation · score 0.32
HbA1c measurement · score 0.31
red blood cell density measurement · score 0.29

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P04921-F1	alphafold	PREDICTED	66.21	—

Amino-acid sequence (128 residues)

MWSTRSPNST AWPLSLEPDP GMASASTTMH TTTIAEPDPG MSGWPDGRME TSTPTIMDIV VIAGVIAAVA IVLVSLLFVM LRYMYRHKGT YHTNEAKGTE FAESADAALQ GDPALQDAGD SSRKEYFI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards