About Insulin-like growth factor 1
Insulin-like growth factor 1 (IGF1) is a protein
from Homo sapiens identified by UniProt accession
P05019, 195 residues long.
MolForge cross-references it against 0 known binders and
1,847 disease associations.
Target properties
| Protein name | Insulin-like growth factor 1 |
|---|
| UniProt accession | P05019 |
|---|
| Gene | IGF1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 195 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (1847)
Diseases linked to this target (Open Targets).
- growth delay due to insulin-like growth factor type 1 deficiency · score 0.77
- sex hormone-binding globulin measurement · score 0.49
- body height · score 0.47
- IGF-1 measurement · score 0.46
- vital capacity · score 0.44
- forced expiratory volume · score 0.42
- peak expiratory flow · score 0.40
- fasting blood insulin measurement · score 0.40
- lean body mass · score 0.39
- body mass index · score 0.39
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P05019-F1 | alphafold | PREDICTED | 59.52 | — |
Amino-acid sequence (195 residues)
MGKISSLPTQ LFKCCFCDFL KVKMHTMSSS HLFYLALCLL TFTSSATAGP ETLCGAELVD ALQFVCGDRG FYFNKPTGYG SSSRRAPQTG IVDECCFRSC DLRRLEMYCA PLKPAKSARS VRAQRHTDMP KTQKYQPPST NKNTKSQRRK GWPKTHPGGE QKEGTEASLQ IRGKKKEQRR EIGSRNAECR GKKGK
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