About Sodium/potassium-transporting ATPase subunit beta-1
Sodium/potassium-transporting ATPase subunit beta-1 (ATP1B1) is a protein
from Homo sapiens identified by UniProt accession
P05026, 303 residues long.
MolForge cross-references it against 0 known binders and
152 disease associations.
Target properties
| Protein name | Sodium/potassium-transporting ATPase subunit beta-1 |
|---|
| UniProt accession | P05026 |
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| Gene | ATP1B1 |
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| Organism | Homo sapiens |
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| Length | 303 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (152)
Diseases linked to this target (Open Targets).
- electrocardiography · score 0.47
- QT interval · score 0.43
- blood coagulation disease · score 0.42
- systolic blood pressure · score 0.41
- pulse pressure measurement · score 0.40
- coronary artery disease · score 0.38
- intraocular pressure measurement · score 0.31
- physical activity measurement · score 0.29
- cataract · score 0.28
- neurodegenerative disease · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P05026-F1 | alphafold | PREDICTED | 89.58 | — |
Amino-acid sequence (303 residues)
MARGKAKEEG SWKKFIWNSE KKEFLGRTGG SWFKILLFYV IFYGCLAGIF IGTIQVMLLT ISEFKPTYQD RVAPPGLTQI PQIQKTEISF RPNDPKSYEA YVLNIVRFLE KYKDSAQRDD MIFEDCGDVP SEPKERGDFN HERGERKVCR FKLEWLGNCS GLNDETYGYK EGKPCIIIKL NRVLGFKPKP PKNESLETYP VMKYNPNVLP VQCTGKRDED KDKVGNVEYF GLGNSPGFPL QYYPYYGKLL QPKYLQPLLA VQFTNLTMDT EIRIECKAYG ENIGYSEKDR FQGRFDVKIE VKS
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