Fructose-bisphosphate aldolase B (ALDOB)

About Fructose-bisphosphate aldolase B

Fructose-bisphosphate aldolase B (ALDOB) is a protein from Homo sapiens identified by UniProt accession P05062, 364 residues long. MolForge cross-references it against 0 known binders and 152 disease associations.

Target properties

Protein name	Fructose-bisphosphate aldolase B
UniProt accession	P05062
Gene	ALDOB
Organism	Homo sapiens
Length	364 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (152)

Diseases linked to this target (Open Targets).

hereditary fructose intolerance · score 0.84
genetic disorder · score 0.52
creatinine measurement · score 0.50
acute liver failure · score 0.46
cystatin C measurement · score 0.40
alkaline phosphatase measurement · score 0.35
apolipoprotein A 1 measurement · score 0.33
lipoprotein measurement · score 0.29
protein measurement · score 0.16
hepatocellular carcinoma · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P05062-F1	alphafold	PREDICTED	95.98	—

Amino-acid sequence (364 residues)

MAHRFPALTQ EQKKELSEIA QSIVANGKGI LAADESVGTM GNRLQRIKVE NTEENRRQFR EILFSVDSSI NQSIGGVILF HETLYQKDSQ GKLFRNILKE KGIVVGIKLD QGGAPLAGTN KETTIQGLDG LSERCAQYKK DGVDFGKWRA VLRIADQCPS SLAIQENANA LARYASICQQ NGLVPIVEPE VIPDGDHDLE HCQYVTEKVL AAVYKALNDH HVYLEGTLLK PNMVTAGHAC TKKYTPEQVA MATVTALHRT VPAAVPGICF LSGGMSEEDA TLNLNAINLC PLPKPWKLSF SYGRALQASA LAAWGGKAAN KEATQEAFMK RAMANCQAAK GQYVHTGSSG AASTQSLFTA CYTY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards