About Arginase-1
Arginase-1 (ARG1) is a protein
from Homo sapiens identified by UniProt accession
P05089, 322 residues long.
MolForge cross-references it against 0 known binders and
454 disease associations.
Target properties
| Protein name | Arginase-1 |
|---|
| UniProt accession | P05089 |
|---|
| Gene | ARG1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 322 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (454)
Diseases linked to this target (Open Targets).
- Argininemia · score 0.83
- hyperargininemia · score 0.78
- glomerular filtration rate · score 0.43
- creatinine measurement · score 0.42
- genetic disorder · score 0.41
- type 2 diabetes mellitus · score 0.33
- vitamin D measurement · score 0.24
- neuritic plaque measurement · score 0.24
- body mass index · score 0.24
- serum metabolite measurement · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P05089-F1 | alphafold | PREDICTED | 96.98 | — |
Amino-acid sequence (322 residues)
MSAKSRTIGI IGAPFSKGQP RGGVEEGPTV LRKAGLLEKL KEQECDVKDY GDLPFADIPN DSPFQIVKNP RSVGKASEQL AGKVAEVKKN GRISLVLGGD HSLAIGSISG HARVHPDLGV IWVDAHTDIN TPLTTTSGNL HGQPVSFLLK ELKGKIPDVP GFSWVTPCIS AKDIVYIGLR DVDPGEHYIL KTLGIKYFSM TEVDRLGIGK VMEETLSYLL GRKKRPIHLS FDVDGLDPSF TPATGTPVVG GLTYREGLYI TEEIYKTGLL SGLDIMEVNP SLGKTPEEVT RTVNTAVAIT LACFGLAREG NHKPIDYLNP PK
Explore Arginase-1 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets