About Aldehyde dehydrogenase, mitochondrial
Aldehyde dehydrogenase, mitochondrial (ALDH2) is a protein
from Homo sapiens identified by UniProt accession
P05091, 517 residues long.
MolForge cross-references it against 0 known binders and
754 disease associations.
Target properties
| Protein name | Aldehyde dehydrogenase, mitochondrial |
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| UniProt accession | P05091 |
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| Gene | ALDH2 |
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| Organism | Homo sapiens |
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| Length | 517 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (754)
Diseases linked to this target (Open Targets).
- alcohol dependence · score 0.63
- AMED syndrome, digenic · score 0.50
- parasitic infection · score 0.46
- alcohol drinking · score 0.43
- mean corpuscular hemoglobin concentration · score 0.43
- alcohol consumption measurement · score 0.41
- cocaine dependence · score 0.41
- serum gamma-glutamyl transferase measurement · score 0.40
- esophageal carcinoma · score 0.39
- Ischemic stroke · score 0.38
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P05091-F1 | alphafold | PREDICTED | 95.92 | — |
Amino-acid sequence (517 residues)
MLRAAARFGP RLGRRLLSAA ATQAVPAPNQ QPEVFCNQIF INNEWHDAVS RKTFPTVNPS TGEVICQVAE GDKEDVDKAV KAARAAFQLG SPWRRMDASH RGRLLNRLAD LIERDRTYLA ALETLDNGKP YVISYLVDLD MVLKCLRYYA GWADKYHGKT IPIDGDFFSY TRHEPVGVCG QIIPWNFPLL MQAWKLGPAL ATGNVVVMKV AEQTPLTALY VANLIKEAGF PPGVVNIVPG FGPTAGAAIA SHEDVDKVAF TGSTEIGRVI QVAAGSSNLK RVTLELGGKS PNIIMSDADM DWAVEQAHFA LFFNQGQCCC AGSRTFVQED IYDEFVERSV ARAKSRVVGN PFDSKTEQGP QVDETQFKKI LGYINTGKQE GAKLLCGGGI AADRGYFIQP TVFGDVQDGM TIAKEEIFGP VMQILKFKTI EEVVGRANNS TYGLAAAVFT KDLDKANYLS QALQAGTVWV NCYDVFGAQS PFGGYKMSGS GRELGEYGLQ AYTEVKTVTV KVPQKNS
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