About Cholesterol side-chain cleavage enzyme, mitochondrial
Cholesterol side-chain cleavage enzyme, mitochondrial (CYP11A1) is a protein
from Homo sapiens identified by UniProt accession
P05108, 521 residues long.
MolForge cross-references it against 0 known binders and
268 disease associations.
Target properties
| Protein name | Cholesterol side-chain cleavage enzyme, mitochondrial |
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| UniProt accession | P05108 |
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| Gene | CYP11A1 |
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| Organism | Homo sapiens |
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| Length | 521 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (268)
Diseases linked to this target (Open Targets).
- Congenital adrenal insufficiency with 46, XY sex reversal OR 46,XY disorder of sex development-adrenal insufficiency due to CYP11A1 deficiency · score 0.77
- 46,XY disorder of sex development - adrenal insufficiency due to CYP11A1 deficiency · score 0.76
- neoplasm · score 0.49
- Cushing syndrome · score 0.48
- classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency · score 0.39
- inherited isolated adrenal insufficiency due to partial CYP11A1 deficiency · score 0.38
- adrenal cortex carcinoma · score 0.38
- congenital adrenal hyperplasia · score 0.38
- adrenal cortex neoplasm · score 0.37
- adrenal gland disease · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P05108-F1 | alphafold | PREDICTED | 91.71 | — |
Amino-acid sequence (521 residues)
MLAKGLPPRS VLVKGCQTFL SAPREGLGRL RVPTGEGAGI STRSPRPFNE IPSPGDNGWL NLYHFWRETG THKVHLHHVQ NFQKYGPIYR EKLGNVESVY VIDPEDVALL FKSEGPNPER FLIPPWVAYH QYYQRPIGVL LKKSAAWKKD RVALNQEVMA PEATKNFLPL LDAVSRDFVS VLHRRIKKAG SGNYSGDISD DLFRFAFESI TNVIFGERQG MLEEVVNPEA QRFIDAIYQM FHTSVPMLNL PPDLFRLFRT KTWKDHVAAW DVIFSKADIY TQNFYWELRQ KGSVHHDYRG ILYRLLGDSK MSFEDIKANV TEMLAGGVDT TSMTLQWHLY EMARNLKVQD MLRAEVLAAR HQAQGDMATM LQLVPLLKAS IKETLRLHPI SVTLQRYLVN DLVLRDYMIP AKTLVQVAIY ALGREPTFFF DPENFDPTRW LSKDKNITYF RNLGFGWGVR QCLGRRIAEL EMTIFLINML ENFRVEIQHL SDVGTTFNLI LMPEKPISFT FWPFNQEATQ Q
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