Protein S100-A8 (S100A8)

About Protein S100-A8

Protein S100-A8 (S100A8) is a protein from Homo sapiens identified by UniProt accession P05109, 93 residues long. MolForge cross-references it against 0 known binders and 865 disease associations.

Target properties

Protein name	Protein S100-A8
UniProt accession	P05109
Gene	S100A8
Organism	Homo sapiens
Length	93 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (865)

Diseases linked to this target (Open Targets).

inborn error of immunity · score 0.37
glioblastoma multiforme · score 0.25
cutaneous melanoma · score 0.22
monocyte percentage of leukocytes · score 0.19
squamous cell lung carcinoma · score 0.19
inflammatory bowel disease · score 0.19
endometrial cancer · score 0.18
head and neck squamous cell carcinoma · score 0.18
monocyte count · score 0.18
protein S100-A12 measurement · score 0.16

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P05109-F1	alphafold	PREDICTED	93.04	—

Amino-acid sequence (93 residues)

MLTELEKALN SIIDVYHKYS LIKGNFHAVY RDDLKKLLET ECPQYIRKKG ADVWFKELDI NTDGAVNFQE FLILVIKMGV AAHKKSHEES HKE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards