Interleukin-4 (IL4)

About Interleukin-4

Interleukin-4 (IL4) is a protein from Homo sapiens identified by UniProt accession P05112, 153 residues long. MolForge cross-references it against 0 known binders and 1,712 disease associations.

Target properties

Protein name	Interleukin-4
UniProt accession	P05112
Gene	IL4
Organism	Homo sapiens
Length	153 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (1712)

Diseases linked to this target (Open Targets).

stroke · score 0.39
eosinophil percentage of leukocytes · score 0.27
head and neck squamous cell carcinoma · score 0.19
breast adenocarcinoma · score 0.18
eosinophil count · score 0.16
asthma · score 0.15
allergic disease · score 0.13
atopic eczema · score 0.12
neoplasm · score 0.12
infection · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P05112-F1	alphafold	PREDICTED	86.77	—

Amino-acid sequence (153 residues)

MGLTSQLLPP LFFLLACAGN FVHGHKCDIT LQEIIKTLNS LTEQKTLCTE LTVTDIFAAS KNTTEKETFC RAATVLRQFY SHHEKDTRCL GATAQQFHRH KQLIRFLKRL DRNLWGLAGL NSCPVKEANQ STLENFLERL KTIMREKYSK CSS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards