Non-histone chromosomal protein HMG-14 (HMGN1)

About Non-histone chromosomal protein HMG-14

Non-histone chromosomal protein HMG-14 (HMGN1) is a protein from Homo sapiens identified by UniProt accession P05114, 100 residues long. MolForge cross-references it against 0 known binders and 111 disease associations.

Target properties

Protein name	Non-histone chromosomal protein HMG-14
UniProt accession	P05114
Gene	HMGN1
Organism	Homo sapiens
Length	100 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (111)

Diseases linked to this target (Open Targets).

platelet count · score 0.19
breast adenocarcinoma · score 0.18
FEV/FVC ratio · score 0.18
platelet crit · score 0.10
neoplasm · score 0.10
lung adenocarcinoma · score 0.08
sex hormone-binding globulin measurement · score 0.08
acute myeloid leukemia · score 0.07
mean platelet volume · score 0.07
serum alanine aminotransferase measurement · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P05114-F1	alphafold	PREDICTED	63.26	—

Amino-acid sequence (100 residues)

MPKRKVSSAE GAAKEEPKRR SARLSAKPPA KVEAKPKKAA AKDKSSDKKV QTKGKRGAKG KQAEVANQET KEDLPAENGE TKTEESPASD EAGEKEAKSD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards